
                                SEQUENCE LISTING

<110> ACADIA PHARMACEUTICALS, INC.
      Olsson, Roger
      Bulow, Anne

<120> CB1-MODULATING COMPOUNDS AND THEIR USE
  

<130> ACADIA.106VPC

<150> 60/852,579          
<151> 2006-10-17  

<160> 4

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 1254
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (1)...(1254)
<223> CB1 receptor

<400> 1
atgaagtcga tcctagatgg ccttgcagat accaccttcc gcaccatcac cactgacctc 60
ctgtacgtgg gctcaaatga cattcagtac gaagacatca aaggtgacat ggcatccaaa 120
ttagggtact tcccacagaa attcccttta acttccttta ggggaagtcc cttccaagag 180
aagatgactg cgggagacaa cccccagcta gtcccagcag accaggtgaa cattacagaa 240
ttttacaaca agtctctctc gtccttcaag gagaatgagg agaacatcca gtgtggggag 300
aacttcatgg acatagagtg tttcatggtc ctgaacccca gccagcagct ggccattgca 360
gtcctgtccc tcacgctggg caccttcacg gtcctggaga acctcctggt gctgtgcgtc 420
atcctccact cccgcagcct ccgctgcagg ccttcctacc acttcatcgg cagcctggcg 480
gtggcagacc tcctggggag tgtcattttt gtctacagct tcattgactt ccacgtgttc 540
caccgcaaag atagccgcaa cgtgtttctg ttcaaactgg gtggggtcac ggcctccttc 600
actgcctccg tgggcagcct gttcctcaca gccatcgaca ggtacatatc cattcacagg 660
cccctggcct ataagaggat tgtcaccagg cccaaggccg tggtggcgtt ttgcctgatg 720
tggaccatag ccattgtgat cgccgtgctg cctctcctgg gctggaactg cgagaaactg 780
caatctgttt gctcagacat tttcccacac attgatgaaa cctacctgat gttctggatc 840
ggggtcacca gcgtactgct tctgttcatc gtgtatgcgt acatgtatat tctctggaag 900
gctcacagcc acgccgtccg catgattcag cgtggcaccc agaagagcat catcatccac 960
acgtctgagg atgggaaggt acaggtgacc cggccagacc aagcccgcat ggacattagg 1020
ttagccaaga ccctggtcct gatcctggtg gtgttgatca tctgctgggg ccctctgctt 1080
gcaatcatgg tgtatgatgt ctttgggaag atgaacaagc tcattaagac ggtgtttgca 1140
ttctgcagta tgctctgcct gctgaactcc accgtgaacc ccatcatcta tgctctgagg 1200
agtaaggacc tgcgacacgc tttccggagc atgtttccct cttgtgaagg ctag       1254

<210> 2
<211> 417
<212> PRT
<213> Artificial Sequence

<220> 
<223> Truncated CB1 protein

<400> 2
Met Lys Ser Ile Leu Asp Gly Leu Ala Asp Thr Thr Phe Arg Thr Ile
 1               5                  10                  15      
Thr Thr Asp Leu Leu Tyr Val Gly Ser Asn Asp Ile Gln Tyr Glu Asp
            20                  25                  30          
Ile Lys Gly Asp Met Ala Ser Lys Leu Gly Tyr Phe Pro Gln Lys Phe
        35                  40                  45              
Pro Leu Thr Ser Phe Arg Gly Ser Pro Phe Gln Glu Lys Met Thr Ala
    50                  55                  60                  
Gly Asp Asn Pro Gln Leu Val Pro Ala Asp Gln Val Asn Ile Thr Glu
65                  70                  75                  80  
Phe Tyr Asn Lys Ser Leu Ser Ser Phe Lys Glu Asn Glu Glu Asn Ile
                85                  90                  95      
Gln Cys Gly Glu Asn Phe Met Asp Ile Glu Cys Phe Met Val Leu Asn
            100                 105                 110         
Pro Ser Gln Gln Leu Ala Ile Ala Val Leu Ser Leu Thr Leu Gly Thr
        115                 120                 125             
Phe Thr Val Leu Glu Asn Leu Leu Val Leu Cys Val Ile Leu His Ser
    130                 135                 140                 
Arg Ser Leu Arg Cys Arg Pro Ser Tyr His Phe Ile Gly Ser Leu Ala
145                 150                 155                 160 
Val Ala Asp Leu Leu Gly Ser Val Ile Phe Val Tyr Ser Phe Ile Asp
                165                 170                 175     
Phe His Val Phe His Arg Lys Asp Ser Arg Asn Val Phe Leu Phe Lys
            180                 185                 190         
Leu Gly Gly Val Thr Ala Ser Phe Thr Ala Ser Val Gly Ser Leu Phe
        195                 200                 205             
Leu Thr Ala Ile Asp Arg Tyr Ile Ser Ile His Arg Pro Leu Ala Tyr
    210                 215                 220                 
Lys Arg Ile Val Thr Arg Pro Lys Ala Val Val Ala Phe Cys Leu Met
225                 230                 235                 240 
Trp Thr Ile Ala Ile Val Ile Ala Val Leu Pro Leu Leu Gly Trp Asn
                245                 250                 255     
Cys Glu Lys Leu Gln Ser Val Cys Ser Asp Ile Phe Pro His Ile Asp
            260                 265                 270         
Glu Thr Tyr Leu Met Phe Trp Ile Gly Val Thr Ser Val Leu Leu Leu
        275                 280                 285             
Phe Ile Val Tyr Ala Tyr Met Tyr Ile Leu Trp Lys Ala His Ser His
    290                 295                 300                 
Ala Val Arg Met Ile Gln Arg Gly Thr Gln Lys Ser Ile Ile Ile His
305                 310                 315                 320 
Thr Ser Glu Asp Gly Lys Val Gln Val Thr Arg Pro Asp Gln Ala Arg
                325                 330                 335     
Met Asp Ile Arg Leu Ala Lys Thr Leu Val Leu Ile Leu Val Val Leu
            340                 345                 350         
Ile Ile Cys Trp Gly Pro Leu Leu Ala Ile Met Val Tyr Asp Val Phe
        355                 360                 365             
Gly Lys Met Asn Lys Leu Ile Lys Thr Val Phe Ala Phe Cys Ser Met
    370                 375                 380                 
Leu Cys Leu Leu Asn Ser Thr Val Asn Pro Ile Ile Tyr Ala Leu Arg
385                 390                 395                 400 
Ser Lys Asp Leu Arg His Ala Phe Arg Ser Met Phe Pro Ser Cys Glu
                405                 410                 415     
Gly
    


<210> 3
<211> 1776
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (127)...(1209)
<223> CB2 protein

<400> 3
caggtcctgg gagaggacag aaaacaactg gactcctcag cccccggcag ctcccagtgc 60
ccagccaccc acaacacaac ccaaagcctt ctagacaagc tcagtggaat ctgaagggcc 120
cacccc atg gag gaa tgc tgg gtg aca gag ata gcc aat ggc tcc aag    168
       Met Glu Glu Cys Trp Val Thr Glu Ile Ala Asn Gly Ser Lys
        1               5                   10
 
gat ggc ttg gat tcc aac cct atg aag gat tac atg atc ctg agt ggt   216
Asp Gly Leu Asp Ser Asn Pro Met Lys Asp Tyr Met Ile Leu Ser Gly
 15                  20                  25                  30
 
ccc cag aag aca gct gtt gct gtg ttg tgc act ctt ctg ggc ctg cta   264
Pro Gln Lys Thr Ala Val Ala Val Leu Cys Thr Leu Leu Gly Leu Leu
                 35                  40                  45
 
agt gcc ctg gag aac gtg gct gtg ctc tat ctg atc ctg tcc tcc cac   312
Ser Ala Leu Glu Asn Val Ala Val Leu Tyr Leu Ile Leu Ser Ser His
             50                  55                  60
 
caa ctc cgc cgg aag ccc tca tac ctg ttc att ggc agc ttg gct ggg   360
Gln Leu Arg Arg Lys Pro Ser Tyr Leu Phe Ile Gly Ser Leu Ala Gly
         65                  70                  75
 
gct gac ttc ctg gcc agt gtg gtc ttt gca tgc agc ttt gtg aat ttc   408
Ala Asp Phe Leu Ala Ser Val Val Phe Ala Cys Ser Phe Val Asn Phe
     80                  85                  90
 
cat gtt ttc cat ggt gtg gat tcc aag gct gtc ttc ctg ctg aag att   456
His Val Phe His Gly Val Asp Ser Lys Ala Val Phe Leu Leu Lys Ile
 95                 100                 105                 110
 
ggc agc gtg act atg acc ttc aca gcc tct gtg ggt agc ctc ctg ctg   504
Gly Ser Val Thr Met Thr Phe Thr Ala Ser Val Gly Ser Leu Leu Leu
                115                 120                 125
 
acc gcc att gac cga tac ctc tgc ctg cgc tat cca cct tcc tac aaa   552
Thr Ala Ile Asp Arg Tyr Leu Cys Leu Arg Tyr Pro Pro Ser Tyr Lys
            130                 135                 140
 
gct ctg ctc acc cgt gga agg gca ctg gtg acc ctg ggc atc atg tgg   600
Ala Leu Leu Thr Arg Gly Arg Ala Leu Val Thr Leu Gly Ile Met Trp
        145                 150                 155
 
gtc ctc tca gca cta gtc tcc tac ctg ccc ctc atg gga tgg act tgc   648
Val Leu Ser Ala Leu Val Ser Tyr Leu Pro Leu Met Gly Trp Thr Cys
    160                 165                 170
 
tgt ccc agg ccc tgc tct gag ctt ttc cca ctg atc ccc aat gac tac   696
Cys Pro Arg Pro Cys Ser Glu Leu Phe Pro Leu Ile Pro Asn Asp Tyr
175                 180                 185                 190
 
ctg ctg agc tgg ctc ctg ttc atc gcc ttc ctc ttt tcc gga atc atc   744
Leu Leu Ser Trp Leu Leu Phe Ile Ala Phe Leu Phe Ser Gly Ile Ile
                195                 200                 205
 
tac acc tat ggg cat gtt ctc tgg aag gcc cat cag cat gtg gcc agc   792
Tyr Thr Tyr Gly His Val Leu Trp Lys Ala His Gln His Val Ala Ser
            210                 215                 220
 
ttg tct ggc cac cag gac agg cag gtg cca gga atg gcc cga atg agg   840
Leu Ser Gly His Gln Asp Arg Gln Val Pro Gly Met Ala Arg Met Arg
        225                 230                 235
 
ctg gat gtg agg ttg gcc aag acc cta ggg cta gtg ttg gct gtg ctc   888
Leu Asp Val Arg Leu Ala Lys Thr Leu Gly Leu Val Leu Ala Val Leu
    240                 245                 250
 
ctc atc tgt tgg ttc cca gtg ctg gcc ctc atg gcc cac agc ctg gcc   936
Leu Ile Cys Trp Phe Pro Val Leu Ala Leu Met Ala His Ser Leu Ala
255                 260                 265                 270
 
act acg ctc agt gac cag gtc aag aag gcc ttt gct ttc tgc tcc atg   984
Thr Thr Leu Ser Asp Gln Val Lys Lys Ala Phe Ala Phe Cys Ser Met
                275                 280                 285
 
ctg tgc ctc atc aac tcc atg gtc aac cct gtc atc tat gct cta cgg   1032
Leu Cys Leu Ile Asn Ser Met Val Asn Pro Val Ile Tyr Ala Leu Arg
            290                 295                 300
 
agt gga gag atc cgc tcc tct gcc cat cac tgc ctg gct cac tgg aag   1080
Ser Gly Glu Ile Arg Ser Ser Ala His His Cys Leu Ala His Trp Lys
        305                 310                 315
 
aag tgt gtg agg ggc ctt ggg tca gag gca aaa gaa gaa gcc ccg aga   1128
Lys Cys Val Arg Gly Leu Gly Ser Glu Ala Lys Glu Glu Ala Pro Arg
    320                 325                 330
 
tcc tca gtc acc gag aca gag gct gat ggg aaa atc act ccg tgg cca   1176
Ser Ser Val Thr Glu Thr Glu Ala Asp Gly Lys Ile Thr Pro Trp Pro
335                 340                 345                 350
 
gat tcc aga gat cta gac ctc tct gat tgc tga tgaggcctct tcccaattta 1229
Asp Ser Arg Asp Leu Asp Leu Ser Asp Cys  *
                355                 360
 
aacaactcaa gtcagaaatc agttcactcc ctggaagaga gagaggggtc ttggcactct 1289
cttcttactt aaaccagtcc cagacaccta gacacggacc cctttttgct gatgagtgtt 1349
gggactgact cctggaagac agcctggcct tgcccacctg cacacagtct gttggatagg 1409
tagggccacg aggagtagcc aggtaggcga gacacaaaaa ggcctgggac agggtcagta 1469
caagtcagga caggcttcat gcctgcatcc tccagagacc accaggagcc aaagcgagcc 1529
tccaggccca gcaatgaggg acttgggaga aatctgagaa gaatgggttg ttctcttggg 1589
aagtcagggt atcagatggg atggacatcc aggtcttctc tctgcctaat tgtcaaggcc 1649
tccttggctc tggagctatg aaaggcccca ctttcaagtc acccttgcca ctgaggaccg 1709
aggactatgc tatgatgagg attaaggtgt tgacttgcct ctttcagaga taaatgacaa 1769
gccttca                                                           1776

<210> 4
<211> 360
<212> PRT
<213> Homo sapiens

<400> 4
Met Glu Glu Cys Trp Val Thr Glu Ile Ala Asn Gly Ser Lys Asp Gly
 1               5                  10                  15      
Leu Asp Ser Asn Pro Met Lys Asp Tyr Met Ile Leu Ser Gly Pro Gln
            20                  25                  30          
Lys Thr Ala Val Ala Val Leu Cys Thr Leu Leu Gly Leu Leu Ser Ala
        35                  40                  45              
Leu Glu Asn Val Ala Val Leu Tyr Leu Ile Leu Ser Ser His Gln Leu
    50                  55                  60                  
Arg Arg Lys Pro Ser Tyr Leu Phe Ile Gly Ser Leu Ala Gly Ala Asp
65                  70                  75                  80  
Phe Leu Ala Ser Val Val Phe Ala Cys Ser Phe Val Asn Phe His Val
                85                  90                  95      
Phe His Gly Val Asp Ser Lys Ala Val Phe Leu Leu Lys Ile Gly Ser
            100                 105                 110         
Val Thr Met Thr Phe Thr Ala Ser Val Gly Ser Leu Leu Leu Thr Ala
        115                 120                 125             
Ile Asp Arg Tyr Leu Cys Leu Arg Tyr Pro Pro Ser Tyr Lys Ala Leu
    130                 135                 140                 
Leu Thr Arg Gly Arg Ala Leu Val Thr Leu Gly Ile Met Trp Val Leu
145                 150                 155                 160 
Ser Ala Leu Val Ser Tyr Leu Pro Leu Met Gly Trp Thr Cys Cys Pro
                165                 170                 175     
Arg Pro Cys Ser Glu Leu Phe Pro Leu Ile Pro Asn Asp Tyr Leu Leu
            180                 185                 190         
Ser Trp Leu Leu Phe Ile Ala Phe Leu Phe Ser Gly Ile Ile Tyr Thr
        195                 200                 205             
Tyr Gly His Val Leu Trp Lys Ala His Gln His Val Ala Ser Leu Ser
    210                 215                 220                 
Gly His Gln Asp Arg Gln Val Pro Gly Met Ala Arg Met Arg Leu Asp
225                 230                 235                 240 
Val Arg Leu Ala Lys Thr Leu Gly Leu Val Leu Ala Val Leu Leu Ile
                245                 250                 255     
Cys Trp Phe Pro Val Leu Ala Leu Met Ala His Ser Leu Ala Thr Thr
            260                 265                 270         
Leu Ser Asp Gln Val Lys Lys Ala Phe Ala Phe Cys Ser Met Leu Cys
        275                 280                 285             
Leu Ile Asn Ser Met Val Asn Pro Val Ile Tyr Ala Leu Arg Ser Gly
    290                 295                 300                 
Glu Ile Arg Ser Ser Ala His His Cys Leu Ala His Trp Lys Lys Cys
305                 310                 315                 320 
Val Arg Gly Leu Gly Ser Glu Ala Lys Glu Glu Ala Pro Arg Ser Ser
                325                 330                 335     
Val Thr Glu Thr Glu Ala Asp Gly Lys Ile Thr Pro Trp Pro Asp Ser
            340                 345                 350         
Arg Asp Leu Asp Leu Ser Asp Cys
        355                 360 

